Publications

pulmonary research publications by Meakins-Christie Laboratories faculty

Pulmonary research publications
Publications are organized by date that notification was received from PubMed

Archive 2008-2015

October 2017

Ye Q, Chourey S, Wang R, Chintam NR, Gravel S, Powell WS, Rokach J. Structure-activity relationship study of β-oxidation resistant indole-based 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) receptor antagonists. Bioorg Med Chem Lett. 2017 Oct 15;27(20):4770-4776. doi: 10.1016/j.bmcl.2017.08.034. Epub 2017 Aug 19.

September 2017

Farahnak S, McGovern TK, Kim R, O’Sullivan M, Chen B, Lee M, Yoshie H, Wang A, Jang J, Al Heialy S, Lauzon AM, Martin JGBasic Fibroblast Growth Factor 2 Is a Determinant of CD4 T Cell-Airway Smooth Muscle Cell Communication through Membrane Conduits. J Immunol. 2017 Sep 18. pii: ji1700164. doi: 10.4049/jimmunol.1700164. [Epub ahead of print]

Paun A, Bergeron ME, Haston CKThe Th1/Th17 balance dictates the fibrosis response in murine radiation-induced lung disease.  Sci Rep. 2017 Sep 14;7(1):11586. doi: 10.1038/s41598-017-11656-5. 

Stana F, Vujovic M, Mayaki D, Leduc-Gaudet JP, Leblanc P, Huck L, Hussain SNADifferential Regulation of the Autophagy and Proteasome Pathways in Skeletal Muscles in Sepsis. Crit Care Med. 2017 Sep;45(9):e971-e979. doi: 10.1097/CCM.0000000000002520.

August 2017

Julian LM, Delaney SP, Wang Y, Goldberg AA, Doré C, Yockell-Lelièvre J, Tam RY, Giannikou K, McMurray F, Shoichet MS, Harper ME, Henske EP, Kwiatkowski DJ, Darling TN, Moss J, Kristof AS, Stanford WL. Human pluripotent stem cell-derived TSC2-haploinsufficient smooth muscle cells recapitulate features of Lymphangioleiomyomatosis. Cancer Res. 2017 Aug 22. pii: canres.0925.2017. doi: 10.1158/0008-5472.CAN-17-0925. [Epub ahead of print]

Bullone M, Vargas A, Elce Y, Martin JG, Lavoie JP. Fluticasone/salmeterol reduces remodelling and neutrophilic inflammation in severe equine asthma. Sci Rep. 2017 Aug 18;7(1):8843. doi: 10.1038/s41598-017-09414-8.

Salter B, Pray C, Radford K, Martin JG, Nair P. Regulation of human airway smooth muscle cell migration and relevance to asthma. Respir Res. 2017 Aug 16;18(1):156. doi: 10.1186/s12931-017-0640-8. Review.

Liang F, Li T, Azuelos I, Giordano C, Liang H, Hussain SN, Matecki S, Petrof BJVentilator-induced diaphragmatic dysfunction in mdx mice. Muscle Nerve. 2017 Aug 8. doi: 10.1002/mus.25760.

Kristof AS, Petrof BJ, Hamid Q, Kolb M, Landry JS, MacKenzie A, McCormack FX, Murawski IJ, Moss J, Rauch F, Rosas IO, Shapiro AJ, Smith BM, Thomas DY, Trapnell BC, Young LR, Zariwala MA; ATS Assembly on Respiratory Cell and Molecular Biology. An Official American Thoracic Society Workshop Report: Translational Research in Rare Respiratory Diseases. Ann Am Thorac Soc. 2017 Aug;14(8):1239-1247. doi: 10.1513/AnnalsATS.201705-406WS.

July 2017

Boikos C, Joseph L, Scheifele D, Lands LC, De Serres G, Papenburg J, Winters N, Chilvers M, Quach C. Adverse events following live-attenuated intranasal influenza vaccination of children with cystic fibrosis: Results from two influenza seasons. Vaccine. 2017 Jul 31. pii: S0264-410X(17)30976-3. doi: 10.1016/j.vaccine.2017.07.068.

Robichaud A, Fereydoonzad L, Limjunyawong N, Rabold R, Allard B, Benedetti A, Martin JG, Mitzner W. Automated Full-Range Pressure-Volume Curves in Mice and Rats. J Appl Physiol (1985). 2017 Jul 27:jap.00856.2016. doi: 10.1152/japplphysiol.00856.2016.

Zago M, Sheridan JA, Traboulsi H, Hecht E, Zhang Y, Guerrina N, Matthews J, Nair P, Eidelman DH, Hamid Q, Baglole CJLow levels of the AhR in chronic obstructive pulmonary disease (COPD)-derived lung cells increases COX-2 protein by altering mRNA stability. PLoS One. 2017 Jul 27;12(7):e0180881. doi: 10.1371/journal.pone.0180881.

Hamamoto Y, Ano S, Allard B, O’Sullivan M, McGovern TK, Martin JGMK reduces inhaled chlorine triggered AHR and airway inflammation in the mouse. Br J Pharmacol. 2017 Jul 18. doi: 10.1111/bph.13953. [Epub ahead of print]

O’Sullivan MJ, Gabriel E, Panariti A, Park CY, Ijpma G, Fredberg JJ, Lauzon AM, Martin JGEpithelial Cells Induce a Cyclooxygenase-1-dependent Endogenous Reduction in Airway Smooth Muscle Contractile Phenotype. Am J Respir Cell Mol Biol. 2017 Jul 14. doi: 10.1165/rcmb.2016-0427OC. Am J Respir Cell Mol Biol. 2017 Jul 14. doi: 10.1165/rcmb.2016-0427OC.

Pamidi S, Redline S, Rapoport D, Ayappa I, Palombini L, Farre R, Kirkness J, Pépin JL, Polo O, Wellman A, Kimoff RJAn Official American Thoracic Society Workshop Report: Noninvasive Identification of Inspiratory Flow Limitation in Sleep Studies. American Thoracic Society Ad Hoc Committee on Inspiratory Flow Limitation. Ann Am Thorac Soc. 2017 Jul;14(7):1076-1085. doi: 10.1513/AnnalsATS.201704-318WS.

June 2017

Mizutani M, Bérubé J, Ahlgren HG, Bernier J, Matouk E, Nguyen D, Rousseau SCorticosteroid-resistant inflammatory signalling in Pseudomonas infected bronchial cells. ERJ Open Res. 2017 Jun 19;3(2). pii: 00144-2016. doi: 10.1183/23120541.00144-2016.

Ojanguren I, Martin JG, Lemiere C. Thymic Stromal Lymphopoietin: A Promising Target in the Treatment of Asthma? Arch Bronconeumol. 2017 Jun 20. pii: S0300-2896(17)30157-6. doi: 10.1016/j.arbres.2017.05.015. [Epub ahead of print] English, Spanish. No abstract available.

Bin Dhuban K, d’Hennezel E, Nagai Y, Xiao Y, Shao S, Istomine R, Alvarez F, Ben-Shoshan M, Ochs H, Mazer B, Li B, Sekine C, Berezov A, Hancock W, Torgerson TR, Greene MI, Piccirillo CA. Suppression by human FOXP3+ regulatory T cells requires FOXP3-TIP60 interactions. Sci Immunol. 2017 Jun 16;2(12). pii: eaai9297. doi: 10.1126/sciimmunol.aai9297.

Cartee GD, Hepple RT, Bamman MM, Zierath JR. Exercise Promotes Healthy Aging of Skeletal Muscle. Cell Metab. 2016 Jun 14;23(6):1034-47. doi: 10.1016/j.cmet.2016.05.007. Review. PMID: 27304505 [PubMed – indexed for MEDLINE]

Stoppe C, Goetzenich A, Whitman G, Ohkuma R, Brown T, Hatzakorzian R, Kristof A, Meybohm P, Mechanick J, Evans A, Yeh D, McDonald B, Chourdakis M, Jones P, Barton R, Tripathi R, Elke G, Liakopoulos O, Agarwala R, Lomivorotov V, Nesterova E, Marx G, Benstoem C, Lemieux M, Heyland DK. Role of nutrition support in adult cardiac surgery: a consensus statement from an International Multidisciplinary Expert Group on Nutrition in Cardiac Surgery. Crit Care. 2017 Jun 5;21(1):131. doi: 10.1186/s13054-017-1690-5.

Kishta OA, Guo Y, Mofarrahi M, Stana F, Lands LC, Hussain SNA. Pulmonary Pseudomonas aeruginosa infection induces autophagy and proteasome proteolytic pathways in skeletal muscles: effects of a pressurized whey protein-based diet in mice.  Food Nutr Res. 2017 Jun 1;61(1):1325309. doi: 10.1080/16546628.2017.1325309. 

May 2017

Mebert AM, Baglole CJ, Desimone MF, Maysinger D. Nanoengineered silica: Properties, applications and toxicity. Food Chem Toxicol. 2017 May 31. pii: S0278-6915(17)30288-0. doi: 10.1016/j.fct.2017.05.054. [Epub ahead of print].

Stana F, Vujovic M, Mayaki D, Leduc-Gaudet JP, Leblanc P, Huck L, Hussain SNADifferential Regulation of the Autophagy and Proteasome Pathways in Skeletal Muscles in Sepsis. Crit Care Med. 2017 May 22. doi: 10.1097/CCM.0000000000002520. [Epub ahead of print]

Mery VP, Gros P, Lafontaine AL, Robinson A, Benedetti A, Kimoff RJ, Kaminska M. Reduced cognitive function in patients with Parkinson disease and obstructive sleep apnea. Neurology. 2017 Mar 21;88(12):1120-1128. doi: 10.1212/WNL.0000000000003738. Epub 2017 Feb 22.

Kaminska M, Noel F, Petrof BJOptimal method for assessment of respiratory muscle strength in neuromuscular disorders using sniff nasal inspiratory pressure (SNIP). PLoS One. 2017 May 16;12(5):e0177723. doi: 10.1371/journal.pone.0177723. eCollection 2017.

Shalaby KH, Al-Heialy S, Tsuchiya K, Farahnak S, McGovern TK, Risse PA, Suh WK, Qureshi ST, Martin JGThe TLR4-TRIF pathway can protect against the development of experimental allergic asthma. Immunology. 2017 May 14. doi: 10.1111/imm.12755. [Epub ahead of print]

Chourey S, Ye Q, Reddy CN, Cossette C, Gravel S, Zeller M, Slobodchikova I, Vuckovic D, Rokach J, Powell WSIn vivo α-hydroxylation of a 2-alkylindole antagonist of the OXE receptor for the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid in monkeys. Biochem Pharmacol. 2017 May 2. pii: S0006-2952(17)30248-4. doi: 10.1016/j.bcp.2017.04.031. [Epub ahead of print]

April 2017

Wang W, Qu X, Dang X, Shang D, Yang L, Li Y, Xu D, Martin JG, Hamid Q, Liu J, Chang Y. Human β-defensin-3 Induces IL-8 Release and Apoptosis in Airway Smooth Muscle Cells. Clin Exp Allergy. 2017 Apr 24. doi: 10.1111/cea.12943. [Epub ahead of print]

Summerhill EM, Hoyle GW, Jordt SE, Jugg BJ, Martin JG, Matalon S, Patterson SE, Prezant DJ, Sciuto AM, Svendsen ER, White CW, Veress LA; ATS Terrorism and Inhalational Disasters Section of the Environmental, Occupational, and Population Health Assembly. An Official American Thoracic Society Workshop Report: Chemical Inhalational Disasters: Biology of Lung Injury, Development of Novel Therapeutics, and Medical Preparedness. Ann Am Thorac Soc. 2017 Apr 18. doi: 10.1513/AnnalsATS.201704-297WS. [Epub ahead of print]

Sterling M, Al-Ismaili Z, McMahon KR, Piccioni M, Pizzi M, Mottes T, Lands LC, Abish S, Fleming AJ, Bennett MR, Palijan A, Devarajan P, Goldstein SL, O’Brien MM, Zappitelli M. Urine biomarkers of acute kidney injury in noncritically ill, hospitalized children treated with chemotherapy. Pediatr Blood Cancer. 2017 Apr 18. doi: 10.1002/pbc.26538. [Epub ahead of print]

Zhao X, Khan N, Gan H, Tzelepis F, Nishimura T, Park SY, Divangahi M, Remold HG. Bcl-xL mediates RIPK3-dependent necrosis in M. tuberculosis-infected macrophages. Mucosal Immunol. 2017 Apr 12. doi: 10.1038/mi.2017.12. [Epub ahead of print]

Downey J, Pernet E, Coulombe F, Allard B, Meunier I, Jaworska J, Qureshi S, Vinh DC, Martin JG, Joubert P, Divangahi MRIPK3 interacts with MAVS to regulate type I IFN-mediated immunity to Influenza A virus infection. PLoS Pathog. 2017 Apr 14;13(4):e1006326. doi: 10.1371/journal.ppat.1006326. [Epub ahead of print]

Gowing SD, Chow SC, Cools-Lartigue JJ, Chen CB, Najmeh S, Jiang HY, Bourdeau F, Beauchamp A, Mancini U, Angers I, Giannias B, Spicer JD, Rousseau S, Qureshi ST, Ferri LE. Gram-Positive Pneumonia Augments Non-Small Cell Lung Cancer Metastasis Via Host Toll-like Receptor 2 Activation. Int J Cancer. 2017 Apr 12. doi: 10.1002/ijc.30734. [Epub ahead of print]

Heyland DK, Weijs PJ, Coss-Bu JA, Taylor B, Kristof AS, O’Keefe GE, Martindale RG. Protein Delivery in the Intensive Care Unit: Optimal or Suboptimal? Nutr Clin Pract. 2017 Apr;32(1_suppl):58S-71S. doi: 10.1177/0884533617691245. Epub 2017 Mar 1.

March 2017

Poon AH, Choy DF, Chouiali F, Ramakrishnan RK, Mahboub B, Audusseau S, Mogas A, Harris JM, Arron JR, Laprise C, Hamid QIncreased Autophagy-Related 5 Gene Expression Is Associated with Collagen Expression in the Airways of Refractory Asthmatics. Front Immunol. 2017 Mar 29;8:355. doi: 10.3389/fimmu.2017.00355. eCollection 2017.

Lands LCDyspnea in Children: What is driving it and how to approach it. Paediatr Respir Rev. 2017 Mar 31. pii: S1526-0542(17)30036-2. doi: 10.1016/j.prrv.2017.03.013. [Epub ahead of print] Review.

Ijpma G, Panariti A, Lauzon AM, Martin JGDirectional preference of airway smooth muscle mass increase in human asthmatic airways. Am J Physiol Lung Cell Mol Physiol. 2017 Mar 30:ajplung.00353.2016. doi: 10.1152/ajplung.00353.2016. [Epub ahead of print]

Harel S, Mayaki D, Sanchez V, Hussain SNNOX2, NOX4, and mitochondrial-derived reactive oxygen species contribute to angiopoietin-1 signaling and angiogenic responses in endothelial cells. Vascul Pharmacol. 2017 Mar 25. pii: S1537-1891(16)30194-X. doi: 10.1016/j.vph.2017.03.002. [Epub ahead of print]

MacMillan NJ, Kapchinsky S, Konokhova Y, Gouspillou G, de Sousa Sena R, Jagoe RT, Baril J, Carver TE, Andersen RE, Richard R, Perrault H, Bourbeau J, Hepple RT, Taivassalo T. Eccentric Ergometer Training Promotes Locomotor Muscle Strength but Not Mitochondrial Adaptation in Patients with Severe Chronic Obstructive Pulmonary Disease. Front Physiol. 2017 Mar 3;8:114. doi: 10.3389/fphys.2017.00114. eCollection 2017 Mar 3.

Boikos C, Papenburg J, Martineau C, Joseph L, Scheifele D, Chilvers M, Lands LC, De Serres G, Quach C. Viral Interference and the Live-attenuated Intranasal Influenza Vaccine: Results from a Pediatric Cohort with Cystic Fibrosis. Hum Vaccin Immunother. 2017 Mar 8:0. doi: 10.1080/21645515.2017.1287641. [Epub ahead of print]

Siddiqui S, Lustig A, Carter A, Sankar M, Daimon CM, Premont RT, Etienne H, van Gastel J, Azmi A, Janssens J, Becker KG, Zhang Y, Wood W, Lehrmann E, Martin JG, Martin B, Taub DD, Maudsley S. Genomic deletion of GIT2 induces a premature age-related thymic dysfunction and systemic immune system disruption. Aging (Albany NY). 2017 Mar 4. doi: 10.18632/aging.101185. [Epub ahead of print]

February 2017

Moussette S, Al Tuwaijri A, Kohan-Ghadr HR, Elzein S, Farias R, Bérubé J, Ho B, Laprise C, Goodyer CG, Rousseau S, Naumova AK. Role of DNA methylation in expression control of the IKZF3-GSDMA region in human epithelial cells. PLoS One. 2017 Feb 27;12(2):e0172707. doi: 10.1371/journal.pone.0172707. eCollection 2017.

Iu M, Zago M, de Souza AR, Bouttier M, Pareek S, White JH, Hamid Q, Eidelman DH, Baglole CJRelB attenuates cigarette smoke extract-induced apoptosis in association with transcriptional regulation of the aryl hydrocarbon receptor. Free Radic Biol Med. 2017 Feb 27. pii: S0891-5849(17)30117-X. doi: 10.1016/j.freeradbiomed.2017.02.045. [Epub ahead of print]

Morrow RM, Picard M, Derbeneva O, Leipzig J, McManus MJ, Gouspillou G, Barbat-Artigas S, Dos Santos C, Hepple RT, Murdock DG, Wallace DC. Mitochondrial energy deficiency leads to hyperproliferation of skeletal muscle mitochondria and enhanced insulin sensitivity. Proc Natl Acad Sci U S A. 2017 Feb 21. pii: 201700997. doi: 10.1073/pnas.1700997114. [Epub ahead of print]

Massoud AH, Kaufman GN, Xue D, Béland M, Dembele M, Piccirillo CA, Mourad W, Mazer BDPeripherally Generated Foxp3+ Regulatory T Cells Mediate the Immunomodulatory Effects of IVIg in Allergic Airways Disease. J Immunol. 2017 Feb 20. pii: 1502361. doi: 10.4049/jimmunol.1502361. [Epub ahead of print]

Gavino C, Landekic M, Zeng J, Wu N, Jung S, Zhong MC, Cohen-Blanchet A, Langelier M, Neyret O, Lejtenyi D, Rochefort C, Cotton-Montpetit J, McCusker C, Mazer B, Veillette A, Vinh DC. Morpholino-based correction of hypomorphic ZAP70 mutation in an adult with combined immunodeficiency. J Allergy Clin Immunol. 2017 Feb 16. pii: S0091-6749(17)30240-3. doi: 10.1016/j.jaci.2017.02.002. [Epub ahead of print]

Mery VP, Gros P, Lafontaine AL, Robinson A, Benedetti A, Kimoff RJ, Kaminska M. Reduced cognitive function in patients with Parkinson disease and obstructive sleep apnea. Neurology. 2017 Feb 22. pii: 10.1212/WNL.0000000000003738. doi: 10.1212/WNL.0000000000003738. [Epub ahead of print]

Martins D, Nguyen DStimulating Central Carbon Metabolism to Re-sensitize Pseudomonas aeruginosa to Aminoglycosides. Cell Chem Biol. 2017 Feb 16;24(2):122-124. doi: 10.1016/j.chembiol.2017.02.004.

Hildebrand KJ, Abrams EM, Vander Leek TK, Upton JE, Mack DP, Kirste L, McCusker C, Kapur S. Primum non nocere – first do no harm. And then feed peanut. Allergy Asthma Clin Immunol. 2017 Feb 8;13:7. doi: 10.1186/s13223-017-0180-2.

Nair P, Martin JG, Cockcroft DC, Dolovich M, Lemiere C, Boulet LP, O’Byrne PM. Airway Hyperresponsiveness in Asthma: Measurement and Clinical Relevance. J Allergy Clin Immunol Pract. 2017 Feb 2. pii: S2213-2198(16)30623-7. doi: 10.1016/j.jaip.2016.11.030. [Epub ahead of print] Review.

Najmeh S, Cools-Lartigue J, Rayes RF, Gowing S, Vourtzoumis P, Bourdeau F, Giannias B, Berube J, Rousseau S, Ferri LE, Spicer JD. Neutrophil Extracellular Traps sequester circulating tumor cells via β1-integrin mediated interactions. Int J Cancer. 2017 Feb 8. doi: 10.1002/ijc.30635. [Epub ahead of print]

Meunier I, Kaufmann E, Downey J, Divangahi MUnravelling the networks dictating host resistance versus tolerance during pulmonary infections. Cell Tissue Res. 2017 Feb 6. doi: 10.1007/s00441-017-2572-5. [Epub ahead of print] Review.

Vassilakopoulos T, Petrof BJA Stimulating Approach to Ventilator-induced Diaphragmatic Dysfunction. Am J Respir Crit Care Med. 2017 Feb 1;195(3):281-282. doi: 10.1164/rccm.201608-1619ED.

January 2017

King IL, Mohrs K, Meli AP, Downey J, Lanthier P, Tzelepis F, Fritz JH, Tumanov AV, Divangahi M, Leadbetter EA, Mohrs M. Intestinal helminth infection impacts the systemic distribution and function of the naive lymphocyte pool. Mucosal Immunol. 2017 Jan 25. doi: 10.1038/mi.2016.127. [Epub ahead of print]

Traboulsi H, Guerrina N, Iu M, Maysinger D, Ariya P, Baglole CJInhaled Pollutants: The Molecular Scene behind Respiratory and Systemic Diseases Associated with Ultrafine Particulate Matter. Int J Mol Sci. 2017 Jan 24;18(2). pii: E243. doi: 10.3390/ijms18020243. Review.

Martin JG, Panariti A. Asthma Phenotypes; Do They Matter? Arch Bronconeumol. 2017 Jan 23. pii: S0300-2896(16)30344-1. doi: 10.1016/j.arbres.2016.11.016. [Epub ahead of print]

Rammal A, Tewfik M, Rousseau SDifferences in RANTES and IL-6 levels among chronic rhinosinusitis patients with predominant gram-negative and gram-positive infection. J Otolaryngol Head Neck Surg. 2017 Jan 17;46(1):7. doi: 10.1186/s40463-016-0183-x.

Rogers S, de Souza AR, Zago M, Iu M, Guerrina N, Gomez A, Matthews J, Baglole CJAryl hydrocarbon receptor (AhR)-dependent regulation of pulmonary miRNA by chronic cigarette smoke exposure. Sci Rep. 2017 Jan 12;7:40539. doi: 10.1038/srep40539.

Dang X, Qu X, Wang W, Liao C, Li Y, Zhang X, Xu D, Baglole CJ, Shang D, Chang Y. Bioinformatic analysis of microRNA and mRNA Regulation in peripheral blood mononuclear cells of patients with chronic obstructive pulmonary disease. Respir Res. 2017 Jan 5;18(1):4. doi: 10.1186/s12931-016-0486-5.

Roussel L, Rousseau SExposure of airway epithelial cells to Pseudomonas aeruginosa biofilm-derived quorum sensing molecules decrease the activity of the anti-oxidant response element bound by NRF2. Biochem Biophys Res Commun. 2017 Jan 3. pii: S0006-291X(17)30009-8. doi: 10.1016/j.bbrc.2017.01.009. [Epub ahead of print]

Anekwe DE, Koo KK, de Marchie M, Goldberg P, Jayaraman D, Spahija J. Interprofessional Survey of Perceived Barriers and Facilitators to Early Mobilization of Critically Ill Patients in Montreal, Canada. J Intensive Care Med. 2017 Jan 1:885066617696846. doi: 10.1177/0885066617696846. [Epub ahead of print]

Nagendra Reddy C, Ye Q, Patel P, Sivendran S, Chourey S, Wang R, Anumolu JR, Grant GE, Powell WS, Rokach J. Design and synthesis of affinity chromatography ligands for the purification of 5-hydroxyeicosanoid dehydrogenase. Bioorg Med Chem. 2017 Jan 1;25(1):116-125. doi: 10.1016/j.bmc.2016.10.017. Epub 2016 Oct 15.

 December 2016

Perez EE, Orange JS, Bonilla F, Chinen J, Chinn IK, Dorsey M, El-Gamal Y, Harville TO, Hossny E, Mazer B, Nelson R, Secord E, Jordan SC, Stiehm ER, Vo AA, Ballow M. Update on the use of immunoglobulin in human disease: A review of evidence. J Allergy Clin Immunol. 2016 Dec 24. pii: S0091-6749(16)31141-1. doi: 10.1016/j.jaci.2016.09.023. [Epub ahead of print]

Goldberg AA, Nkengfac B, Sanchez AM, Moroz N, Qureshi ST, Koromilas AE, Wang S, Burelle Y, Hussain SN, Kristof ASRegulation of ULK1 expression and autophagy by STAT1. J Biol Chem. 2016 Dec 23. pii: jbc.M116.771584. doi: 10.1074/jbc.M116.771584. [Epub ahead of print]

Roussel L, LaFayette S, Nguyen D, Baglole CJ, Rousseau SDifferential Contribution of the Aryl-Hydrocarbon Receptor and Toll-Like Receptor Pathways to IL-8 Expression in Normal and Cystic Fibrosis Airway Epithelial Cells Exposed to Pseudomonas aeruginosa. Front Cell Dev Biol. 2016 Dec 22;4:148. doi: 10.3389/fcell.2016.00148.

Pothoven KL, Norton JE, Suh LA, Carter RG, Harris KE, Biyasheva A, Welch K, Shintani-Smith S, Conley DB, Liu MC, Kato A, Avila PC, Hamid Q, Grammer LC 3rd, Peters AT, Kern RC, Tan BK, Schleimer RP. Neutrophils are a major source of the epithelial barrier disrupting cytokine Oncostatin M in mucosal airways disease. J Allergy Clin Immunol. 2016 Dec 16. pii: S0091-6749(16)31462-2. doi: 10.1016/j.jaci.2016.10.039. [Epub ahead of print]

Falegan OS, Vogel HJ, Hittel DS, Koch LG, Britton SL, Hepple RT, Shearer J. High aerobic capacity mitigates changes in the plasma metabolic profile associated with aging. J Proteome Res. 2016 Dec 12. [Epub ahead of print]

Xue D, Desjardins M, Kaufman GN, Béland M, Al-Tamemi S, Ahmed E, Tao S, Friedel RH, Mourad W, Mazer BDSemaphorin 4C: A Novel Component of B-Cell Polarization in Th2-Driven Immune Responses. Front Immunol. 2016 Dec 7;7:558. doi: 10.3389/fimmu.2016.00558.

November 2016

Xue D, Kaufman GN, Dembele M, Beland M, Massoud AH, Mindt BC, Fiter R, Fixman ED, Martin JG, Friedel RH, Divangahi M, Fritz JH, Mazer BDSemaphorin 4C Protects against Allergic Inflammation: Requirement of Regulatory CD138+ Plasma Cells. J Immunol. 2016 Nov 23. pii: 1600831. [Epub ahead of print]

Magder S, Serri K, Verscheure S, Chauvin R, Goldberg PActive Expiration and the Measurement of Central Venous Pressure. J Intensive Care Med. 2016 Nov 20. pii: 0885066616678578. [Epub ahead of print]

Ano S, Panariti A, Allard B, O’Sullivan M, McGovern TK, Hamamoto Y, Ishii Y, Yamamoto M, Powell WS, Martin JGInflammation and airway hyperresponsiveness after chlorine exposure are prolonged by Nrf2 deficiency in mice. Free Radic Biol Med. 2016 Nov 12. pii: S0891-5849(16)31040-1. doi: 10.1016/j.freeradbiomed.2016.11.017. [Epub ahead of print]

MacFadden-Murphy E, Roussel L, Martel G, Bérubé J, Rousseau SDecreasing SMPD1 activity in BEAS-2B bronchial airway epithelial cells results in increased NRF2 activity, cytokine synthesis and neutrophil recruitment. Biochem Biophys Res Commun. 2016 Nov 16. pii: S0006-291X(16)31950-7. doi: 10.1016/j.bbrc.2016.11.087. [Epub ahead of print]

Altit G, Dancea A, Renaud C, Perreault T, Lands LC, Sant’Anna G. Pathophysiology, screening and diagnosis of pulmonary hypertension in infants with bronchopulmonary dysplasia – A review of the literature. Paediatr Respir Rev. 2016 Nov 9. pii: S1526-0542(16)30125-7. doi: 10.1016/j.prrv.2016.11.002. [Epub ahead of print]

October 2016

Fitzgerald DA, Eber E, Lands LCSecondary Pulmonary Hypertension: Who to consider, how to confirm and when to follow-up. Paediatr Respir Rev. 2016 Oct 31. pii: S1526-0542(16)30122-1. doi: 10.1016/j.prrv.2016.10.008. [Epub ahead of print]

Das S, Miller M, Beppu AK, Mueller J, McGeough MD, Vuong C, Karta MR, Rosenthal P, Chouiali F, Doherty TA, Kurten RC, Hamid Q, Hoffman HM, Broide DH. GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation. Proc Natl Acad Sci U S A. 2016 Oct 31. pii: 201610433. [Epub ahead of print]

Pai M, Behr MA, Dowdy D, Dheda K, Divangahi M, Boehme CC, Ginsberg A, Swaminathan S, Spigelman M, Getahun H, Menzies D, Raviglione M. Tuberculosis. Nat Rev Dis Primers. 2016 Oct 27;2:16076. doi: 10.1038/nrdp.2016.76.

Cossette C, Chourey S, Ye Q, Nagendra Reddy C, Gore V, Gravel S, Slobodchikova I, Vuckovic D, Rokach J, Powell WSPharmacokinetics and metabolism of selective oxoeicosanoid (OXE) receptor antagonists and their effects on 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE)-induced granulocyte activation in monkeys. J Med Chem. 2016 Oct 21. PMID: 27766872. DOI:10.1021/acs.jmedchem.6b00895

Matouk E, Nguyen D, Benedetti A, Bernier J, Gruber J, Landry J, Rousseau S, Ahlgren HG, Lands LC, Wojewodka G, Radzioch D. C-Reactive Protein in Stable Cystic Fibrosis: An Additional Indicator of Clinical Disease Activity and Risk of Future Pulmonary Exacerbations. J Pulm Respir Med. 2016 Oct 14;6(5):1000375. doi: 10.4172/2161-105X.1000375.

Gouspillou G, Hepple RTEditorial: Mitochondria in Skeletal Muscle Health, Aging and Diseases. Front Physiol. 2016 Oct 6;7:446. No abstract available.

Lau L, Al-Ismaili Z, Harel-Sterling M, Pizzi M, Caldwell JS, Piccioni M, Lands LC, Mottes T, Devarajan P, Goldstein SL, Bennett MR, Zappitelli M. Serum cystatin C for acute kidney injury evaluation in children treated with aminoglycosides. Pediatr Nephrol. 2016 Oct 14.

Genest J, Hébert TE, Martin JThe Louis and Artur Lucian Award in Cardiovascular Diseases at McGill University. Circ Res. 2016 Oct 14;119(9):975-977.

Narayanapillai SC, Lin SH, Leitzman P, Upadhyaya P, Baglole CJ, Xing C. Dihydromethysticin (DHM) blocks tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced O6-methylguanine independent of aryl hydrocarbon receptor (AhR) in C57BL/6 female mice. Chem Res Toxicol. 2016 Oct 11. PMID: 27728767 [PubMed]

Codere-Maruyama T, Schricker T, Shum-Tim D, Wykes L, Nitschmann E, Guichon C, Kristof AS, Hatzakorzian R. Hyperinsulinemic-normoglycemic clamp administered together with amino acids induces anabolism after cardiac surgery. Am J Physiol Regul Integr Comp Physiol. 2016 Oct 5:ajpregu.00334.2016.

September 2016

Spendiff S, Vuda M, Gouspillou G, Aare S, Perez A, Morais JA, Jagoe RT, Filion ME, Glicksman R, Kapchinsky S, MacMillan N, Pion CH, Aubertin-Leheudre M, Hettwer S, Correa JA, Taivassalo T, Hepple RTDenervation drives mitochondrial dysfunction in skeletal muscle of octogenarians. J Physiol. 2016 Sep 13. doi: 10.1113/JP272487. [Epub ahead of print]

Al-Kufaidy R, Vazquez-Tello A, BaHammam AS, Hamid Q, Al-Muhsen S, Halwani R. IL-17 enhances the migration of B cells during asthma by inducing CXCL13 chemokine production in structural lung cells. J Allergy Clin Immunol. 2016 Sep 14. pii: S0091-6749(16)30958-7. doi: 10.1016/j.jaci.2016.07.037. [Epub ahead of print]

Aare S, Spendiff S, Vuda M, Elkrief D, Perez A, Wu Q, Mayaki D, Hussain SN, Hettwer S, Hepple RTFailed reinnervation in aging skeletal muscle. Skelet Muscle. 2016 Sep 1;6(1):29. doi: 10.1186/s13395-016-0101-y. eCollection 2016.

St-Jean-Pelletier F, Pion CH, Leduc-Gaudet JP, Sgarioto N, Zovilé I, Barbat-Artigas S, Reynaud O, Alkaterji F, Lemieux FC, Grenon A, Gaudreau P, Hepple RT, Chevalier S, Belanger M, Morais JA, Aubertin-Leheudre M, Gouspillou G. The impact of ageing, physical activity, and pre-frailty on skeletal muscle phenotype, mitochondrial content, and intramyocellular lipids in men. J Cachexia Sarcopenia Muscle. 2016 Sep 2. doi: 10.1002/jcsm.12139. [Epub ahead of print]

August 2016

Boikos C, Joseph L, Martineau C, Papenburg J, Scheifele D, Lands LC, De Serres G, Chilvers M, Quach C. Influenza Virus Detection Following Administration of Live-Attenuated Intranasal Influenza Vaccine in Children With Cystic Fibrosis and Their Healthy Siblings. Open Forum Infect Dis. 2016 Aug 30;3(4):ofw187.

Srinivasa BT, Restori KH, Shan J, Cyr L, Xing L, Lee S, Ward BJ, Fixman EDSTAT6 inhibitory peptide given during RSV infection of neonatal mice reduces exacerbated airway responses upon adult reinfection. J Leukoc Biol. 2016 Aug 26. pii: jlb.4A0215-062RR. [Epub ahead of print]

July 2016

Matecki S, Dridi H, Jung B, Saint N, Reiken SR, Scheuermann V, Mrozek S, Santulli G, Umanskaya A, Petrof BJ, Jaber S, Marks AR, Lacampagne A. Leaky ryanodine receptors contribute to diaphragmatic weakness during mechanical ventilation. Proc Natl Acad Sci U S A. 2016 Jul 25. pii: 201609707. [Epub ahead of print]

Goldberg AA, Joung KB, Mansuri A, Kang Y, Echavarria R, Nikolajev L, Sun Y, Yu JJ, Laporte SA, Schwertani A, Kristof ASOncogenic effects of urotensin-II in cells lacking tuberous sclerosis complex-2. Oncotarget. 2016 Jul 21. doi: 10.18632/oncotarget.10748. [Epub ahead of print]

Hebestreit H, Arets HG, Aurora P, Boas S, Cerny F, Hulzebos EH, Karila C, Lands LC, Lowman JD, Swisher A, Urquhart DS; Cystic Fibrosis Exercise Working Group. Authors’ Reply: Statement on Exercise testing in Cystic Fibrosis. Respiration. 2016 Jul 1;92(1):63-64. [Epub ahead of print]

June 2016

Schnúr A, Hegyi P, Rousseau S, Lukacs GL, Veit G. Epithelial Anion Transport as Modulator of Chemokine Signaling. Mediators Inflamm. 2016;2016:7596531. Epub 2016 Jun 12. Review.

Boisvert AA, Cheng MP, Sheppard DC, Nguyen D. Microbial Biofilms in Pulmonary and Critical Care Diseases. Ann Am Thorac Soc. 2016 Jun 27. [Epub ahead of print]

Chan W, Ismail H, Mayaki D, Sanchez V, Tiedemann K, Davis EC, Hussain SNFibulin-5 Regulates Angiopoietin-1/Tie-2 Receptor Signaling in Endothelial Cells. PLoS One. 2016 Jun 15;11(6):e0156994. doi: 10.1371/journal.pone.0156994. eCollection 2016.

Cartee GD, Hepple RT, Bamman MM, Zierath JR. Exercise Promotes Healthy Aging of Skeletal Muscle. Cell Metab. 2016 Jun 14;23(6):1034-47. doi: 10.1016/j.cmet.2016.05.007. Review.

May 2016

Taivassalo T, Hussain SNContribution of the Mitochondria to Locomotor Muscle Dysfunction in Patients With COPD. Chest. 2016 May;149(5):1302-12. doi: 10.1016/j.chest.2015.11.021. Epub 2015 Dec 12. Review.

Silva-Barrios S, Smans M, Duerr CU, Qureshi ST, Fritz JH, Descoteaux A, Stäger S. Innate Immune B Cell Activation by Leishmania donovani Exacerbates Disease and Mediates Hypergammaglobulinemia. Cell Rep. 2016 May 31. pii: S2211-1247(16)30611-8. doi: 10.1016/j.celrep.2016.05.028.

Hathroubi S, Mekni MA, Domenico P, Nguyen D, Jacques M. Biofilms: Microbial Shelters Against Antibiotics. Microb Drug Resist. 2016 May 23. [Epub ahead of print]

McGovern T, Goldberger M, Chen M, Allard B, Hamamoto Y, Kanaoka Y, Austen KF, Powell WSMartin JGCysLT1 Receptor Is Protective against Oxidative Stress in a Model of Irritant-Induced Asthma. J Immunol. 2016 May 25. pii: 1501084. [Epub ahead of print]

Walsh CJ, Zaihra T, Benedetti A, Fugère C, Olivenstein R, Lemière C, Hamid QMartin JGExacerbation risk in severe asthma is stratified by inflammatory phenotype using longitudinal measures of sputum eosinophils. Clin Exp Allergy. 2016 May 23. doi: 10.1111/cea.12762.

Ruffin M, Bilodeau C, Maillé É, LaFayette SL, McKay GA, Trinh NT, Beaudoin T, Desrosiers MY, Rousseau SNguyen D, Brochiero E. Quorum-sensing inhibition abrogates the deleterious impact of Pseudomonas aeruginosa on airway epithelial repair. FASEB J. 2016 May 13. pii: fj.201500166R. [Epub ahead of print]

Zaihra T, Walsh CJ, Ahmed S, Fugère C, Hamid QA, Olivenstein R, Martin JG, Benedetti A. Phenotyping of difficult asthma using longitudinal physiological and biomarker measurements reveals significant differences in stability between clusters. BMC Pulm Med. 2016 May 10;16(1):74. doi: 10.1186/s12890-016-0232-2.

Withington DE, Fontela PS, Harrington KP, Lands LCPerioperative Steroids in Pediatric Cardiopulmonary Bypass: We Still Do Not Have All the Answers. Pediatr Crit Care Med. 2016 May;17(5):475. doi: 10.1097/PCC.0000000000000679.

April 2016

Mak DY, Sykes J, Stephenson AL, Lands LCThe benefits of newborn screening for cystic fibrosis: The Canadian experience. J Cyst Fibros. 2016 Apr 21. pii: S1569-1993(16)30018-2. doi: 10.1016/j.jcf.2016.04.001. [Epub ahead of print]

Dessalle K, Narayanan V, Kyoh S, Mogas A, Halayko AJ, Nair P, Baglole CJEidelman DH, Ludwig MSHamid QHuman bronchial and parenchymal fibroblasts display differences in basal inflammatory phenotype and response to IL-17A. Clin Exp Allergy. 2016 Apr 15. doi: 10.1111/cea.12744. [Epub ahead of print]

Pamidi S, Marc I, Simoneau G, Lavigne L, Olha A, Benedetti A, Sériès F, Fraser W, Audibert F, Bujold E, Gagnon R, Schwartzman K,  Kimoff RJMaternal sleep-disordered breathing and the risk of delivering small for gestational age infants: a prospective cohort study. Thorax. 2016 Apr 15. pii: thoraxjnl-2015-208038. doi: 10.1136/thoraxjnl-2015-208038. [Epub ahead of print]

Dauletbaev N, Lands LCCould relative abundance of airway lipoxins be the clue to restore corticosteroid sensitivity in severe asthma? J Allergy Clin Immunol. 2016 Apr 12. pii: S0091-6749(16)00377-8. doi: 10.1016/j.jaci.2016.02.012. [Epub ahead of print] No abstract available.

Dos Santos C, Hussain SN, Mathur S, Picard M, Herridge M, Correa J, Bain A, Guo Y, Advani A, Advani SL, Tomlinson G, Katzberg H, Streutker CJ, Cameron JI, Schols A, Gosker H, Batt J; MEND ICU group, the RECOVER Program investigators and the Canadian Critical Care Translational Biology Group. Mechanisms of Chronic Muscle Wasting and Dysfunction After an Intensive Care Unit Stay: A Pilot Study. Am J Respir Crit Care Med. 2016 Apr 8. [Epub ahead of print]

Tarnopolsky M, Katzberg H, Petrof BJ, Sirrs S, Sarnat HB, Myers K, Dupré N, Dodig D, Genge A, Venance SL, Korngut L, Raiman J, Khan A. Pompe Disease: Diagnosis and Management. Evidence-Based Guidelines from a Canadian Expert Panel. Can J Neurol Sci. 2016 Apr 8:1-14. [Epub ahead of print]

Lands LC, Stanojevic S. Oral non-steroidal anti-inflammatory drug therapy for lung disease in cystic fibrosis. Cochrane Database Syst Rev. 2016 Apr 7;4:CD001505. [Epub ahead of print] Review.

March 2016

Hussain SN, Cornachione AS, Guichon C, Al Khunaizi A, de Souza Leite F, Petrof BJ, Mofarrahi M, Moroz N, de Varennes B,  Goldberg P, Rassier DE. Prolonged controlled mechanical ventilation in humans triggers myofibrillar contractile dysfunction and myofilament protein loss in the diaphragm. Thorax. 2016 Mar 31. pii: thoraxjnl-2015-207559. doi: 10.1136/thoraxjnl-2015-207559. [Epub ahead of print]

O’Keefe AW, Halbrich M, Ben-Shoshan M, McCusker CPrimary immunodeficiency for the primary care provider. Paediatr Child Health. 2016 Mar;21(2):e10-4. Review.

Poon AH, Hamid QSevere Asthma: Have We Made Progress? Ann Am Thorac Soc. 2016 Mar;13 Suppl 1:S68-77. doi: 10.1513/AnnalsATS.201508-514MG.

Hepple RTImpact of Aging on Mitochondrial Function in Cardiac and Skeletal Muscle. Free Radic Biol Med. 2016 Mar 23. pii: S0891-5849(16)00123-4. doi: 10.1016/j.freeradbiomed.2016.03.017. [Epub ahead of print]

Power GA, Allen MD, Gilmore KJ, Stashuk DW, Doherty TJ, Hepple RT, Taivassalo T, Rice CL. Motor unit number and transmission stability in octogenarian world class athletes: Can age-related deficits be outrun?  J Appl Physiol (1985). 2016 Mar 24:jap.00149.2016. doi: 10.1152/japplphysiol.00149.2016.

Miller M, Esnault S, Kurten RC, Kelly EA, Beppu A, Das S, Rosenthal P, Ramsdell J, Croft M, Zuraw B, Jarjour N, Hamid Q, Broide DH. Segmental allergen challenge increases levels of airway follistatin-like 1 in patients with asthma.  J Allergy Clin Immunol. 2016 Mar 18. pii: S0091-6749(16)00256-6. doi: 10.1016/j.jaci.2016.01.019.

Lauzon AMMartin JGAirway hyperresponsiveness; smooth muscle as the principal actor. F1000Res. 2016 Mar 9;5. pii: F1000 Faculty Rev-306. doi: 10.12688/f1000research.7422.1. eCollection 2016.

Gohal G, McCusker CMazer B, Alizadehfar R, Lejtenyi D, Ben-Shoshan M.  T-cell receptor phenotype pattern in atopic children using commercial fluorescently labeled antibodies against 21 human class-specific v segments for the tcrβ chain (vβ) of peripheral blood: a cross sectional study. Allergy Asthma Clin Immunol. 2016 Mar 2;12:10. doi: 10.1186/s13223-016-0115-3. eCollection 2016.

February 2016

Labonté LE, Bourbeau J, Daskalopoulou SS, Zhang M, Coulombe P, Garland K, Baglole CJClub Cell-16 and RelB as Novel Determinants of Arterial Stiffness in Exacerbating COPD Patients. PLoS One. 2016 Feb 25;11(2):e0149974. doi: 10.1371/journal.pone.0149974.

Konokhova Y, Spendiff S, Jagoe RT, Aare S, Kapchinsky S, MacMillan NJ, Rozakis P, Picard M, Aubertin-Leheudre M, Pion CH, Bourbeau J, Hepple RT, Taivassalo T. Failed upregulation of TFAM protein and mitochondrial DNA in oxidatively deficient fibers of chronic obstructive pulmonary disease locomotor muscle. Skelet Muscle. 2016 Feb 18;6:10.

January 2016

Mojumdar K, Giordano C, Lemaire C, Liang F,  Divangahi MQureshi STPetrof BJDivergent impact of Toll-like receptor 2 deficiency on repair mechanisms in healthy muscle versus Duchenne muscular dystrophy. J Pathol. 2016 Jan 21. doi: 10.1002/path.4689. [Epub ahead of print].

Bazett M, Bergeron ME, Haston CKStreptomycin treatment alters the intestinal microbiome, pulmonary T cell profile and airway hyperresponsiveness in a cystic fibrosis mouse model. Sci Rep. 2016 Jan 12;6:19189. doi: 10.1038/srep19189.

Farias R, Rousseau S. The TAK1→IKKβ→TPL2→MKK1/MKK2 Signaling Cascade Regulates IL-33 Expression in Cystic Fibrosis Airway Epithelial Cells Following Infection by Pseudomonas aeruginosa. Front Cell Dev Biol. 2016 Jan 11;3:87. doi: 10.3389/fcell.2015.00087.

Klionsky DJ, Hamid Q, Hussain SNPetrof BJ, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016 Jan 2;12(1):1-222.