β-Glucan Induces Protective Trained Immunity against Mycobacterium tuberculosis Infection: A Key Role for IL-1

Using β-glucan to help fight TB Infection

Congratulations to Dr. Nargis Khan and Dr. Eva Kaufmann, postdoctoral fellows with Dr. Maziar Divangahi for their latest Cell Reports publication. Their work shows that β-glucan induces protective trained immunity in human monocytes infected with Mycobacterium tuberculosis, as well as in mice infected with Mycobacterium tuberculosis. Their work is paving the way for both prophylactic and therapeutic use of β-glucan in TB.

Some highlights from the article:

  • β-glucan induces protective trained immunity in human monocytes infected with Mtb
  • β-glucan induces protective trained immunity in mice infected with Mtb
  • β-glucan-mediated protection against Mtb is dependent on IL-1 signaling
  • β-glucan increases expansion of hematopoietic progenitors and myelopoiesis via IL-1

Read the entire paper here: https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30587-8