Chronic Airways Disease
Chronic Airways Disease Theme: Chronic airway diseases such as asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis, and bronchopulmonary dysplasia share common features of chronic airflow obstruction and structural changes of the airways. These disorders are associated with an underlying inflammatory process that is driven by genetic susceptibility as well as environmental factors such as allergens and cigarette smoke. The main research questions being investigated focus on elucidating the basic mechanisms that lead to the development of chronic airways disease. Studies are also attempting to identify and characterize the clinical heterogeneity of these diseases in order to better personalize prognostic, diagnostic and therapeutic tools.
Major scientific objectives of the chronic airways diseases theme include: (1) Elucidate pathogenetic mechanisms and develop novel therapeutics for allergic inflammation & airway hyperresponsiveness. (2) Understand the cellular and molecular basis for irritant (including air pollution & cigarette smoke) -induced lung disease, and its relevance to COPD and the Asthma-COPD Overlap Syndrome (ACOS). (3) Ascertain the biological basis for different asthma phenotypes, particularly severe asthma that is resistant to usual therapies.
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