Dr. Dao Nguyen investigated the behavior of Pseudomonas aeruginosa, a common bacteria in patients with Cystic Fibrosis. Her research identified that when bacteria are starved, they develop a starvation-signaling stringent response, which allows them to better adapt and survive. This research showed that inactivating this protective mechanism can sensitize biofilms to various antibiotics, thus providing new insights on the mechanisms of antibiotic tolerance.
View the full publication here: Active starvation responses mediate antibiotic tolerance in biofilms and nutrient-limited bacteria. Nguyen D, Joshi-Datar A, Lepine F, Bauerle E, Olakanmi O, Beer K, McKay G, Siehnel R, Schafhauser J, Wang Y, Britigan BE, Singh PK. Science. 2011 Nov 18;334(6058):982-6. doi: 10.1126/science.1211037. PMID: 22096200