Category Archives: Sleep-Disordered Breathing

Sleep-Disordered Breathing Theme: Obstructive sleep apnea (OSA) is a condition characterized by repeated episodes of upper airway obstruction during sleep. As such, OSA leads to intermittent hypoxia-reoxygenation, sleep fragmentation, hemodynamic fluctuations, sympathetic neural activation, oxidative stress and increased systemic inflammation. The McGill University Health Centre (MUHC) Sleep Group has an active and expanding translational research program that directly investigates the impact of OSA on common diseases. This include neurodegenerative disorders, insulin sensitivity and metabolic health, as well as pregnancy outcomes for both mother and child. The impact of intermittent hypoxia on respiratory and peripheral muscle structure, function, inflammation and metabolism is also being examined.

Major scientific objectives for the sleep-disordered breathing theme include: (1) Investigate effects of intermittent hypoxia on respiratory and peripheral muscle structure, function, inflammation and metabolism. (2) Determine effects of OSA treatment on key clinical outcomes in two common neurodegenerative disorders, multiple sclerosis and Parkinson’s disease. (3) Evaluate whether OSA treatment improves insulin sensitivity and other indices of cardiometabolic health in patients. (4) Determine optimal approaches to treatment of maternal OSA, focusing on both maternal and fetal pregnancy outcomes.

View posts, news, and publications related to this research theme below.

respiratory research grant results at the meakins-christie laboratories

Funding News – CIHR Project Grant

Congratulations to the following Spring 2019 Project Grant Recipients

Dr. Sushmita Pamidi received funding for her project co-led with Evelyn Constantin (CHHD program) entitled “Maternal sleep-disordered breathing during pregnancy and long-term health outcomes in children: the 3D pregnancy and birth cohort”. Dr. John Kimoff is a co-investigator on the grant.

Dr. Larry Lands is a co-applicant with Dr. Michael Parkins (University of Calgary) for the grant entitled “The influence of Cytomegalovirus infection on cystic fibrosis disease progression”.

View full CIHR Funding Decisions for the 2019 Spring Project Grant Competition.