RESP Journal Club

2020-2021 RESP Journal Club
Welcome to the joint RESP JOURNAL CLUB with RECRU and Meakins members. This journal club is open to all clinical and research faculty, trainees, fellows, and residents. The goal of this journal club is to critically evaluate a research article (or topic) from both clinical and fundamental science perspectives. Publications will be jointly chosen by RECRU and Meakins faculty members, who will facilitate discussion of the article. The publications will cover the various research themes of the RESP program, with a focus on translational research. Presentations will be delivered by faculty and/or trainees/fellows and all discussions will be moderated. Articles will be distributed 1 week in advance of the Journal Club date.
Frequency: Monthly on Fridays at 12 noon via ZOOM

Friday September 18, 2020Benjamin SmithSimon RousseauEarly-onset emphysema in a large French-Canadian family: a genetic investigation
Lancet Respir Med. 2019 May;7(5):427-436.
Friday October 16, 2020Sushmita PamidiBasil PetrofSleep modulates haematopoiesis and protects against atherosclerosis
Nature. 2019 Feb;566(7744):383-387
Symptom Subtypes of Obstructive Sleep Apnea Predict Incidence of Cardiovascular Outcomes
Am J Respir Crit Care Med. 2019 Aug 15;200(4):493-506.
Friday November 20, 2020John KimoffCarolyn BagloleFactors associated with COVID-19-related death using OpenSAFELY
Nature 584, 430–436 (2020)
Cigarette Smoke Exposure and Inflammatory Signaling Increase the Expression of the SARS-CoV2 Receptor ACE2 in the Respiratory Tract
Dev Cell 2020 Jun 8;53(5):514-529.e3
Friday December 11, 2020Sana SwalehDao NguyenIntravenous versus oral antibiotics for eradication of Pseudomonas aeruginosa in cystic fibrosis (TORPEDO-CF): a randomised controlled trial
Lancet Respir Med 2020 Oct;8(10):975-986
Pseudomonas aeruginosa Strain-sharing in Early Infection Among Children With Cystic Fibrosis
Clin Infect Dis 2020 Jun 16 
Friday January 29, 2021Faiz Ahmad KhanChest x-ray analysis with deep learning-based software as a triage test for pulmonary tuberculosis: a prospective study of diagnostic accuracy for culture-confirmed disease
Lancet Digit Health 2020; 2: e573–81
Friday February 12, 2021Kevin SchwartzmanMaziar DivanagahiFinal Analysis of a Trial of M72/AS01E Vaccine to Prevent Tuberculosis 
N Engl J Med 2019;381:2429-39
Prevention of M. tuberculosis Infection with H4:IC31 Vaccine or BCG Revaccination
N Engl J Med 2018;379:138-49
Friday March 19, 2021Deborah AssayagGregory FonsecaTelomere Length and Genetic Variant Associations with Interstitial Lung Disease Progression and Survival
Eur Respir J. 2019 Apr 11;53(4):1801641
Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis
Sci Adv. 2020 Jul 8;6(28):eaba1983
Friday April 16, 2021Marta KaminskaThe Sleep Apnea-specific Pulse Rate Response Predicts Cardiovascular Morbidity and Mortality
Am J Respir Crit Care Med. 2021 Jan 6. Epub ahead of print. PMID: 33406013
Friday May 14, 2021Nicole EzerJames MartinInhaled budesonide in the treatment of early COVID-19 (STOIC): a phase 2, open-label, randomised controlled trial
Lancet Respir Med. 2021 Apr 9. Epub ahead of print. Erratum in: Lancet Respir Med. 2021 Apr 14: PMID: 33844996
The Inhaled Steroid Ciclesonide Blocks SARS-CoV-2 RNA Replication by Targeting the Viral Replication-Transcription Complex in Cultured Cells
J Virol. 2020 Dec 9;95(1):e01648-20. PMID: 33055254
Friday June 11, 2021Bryan RossDennis JensenSubmaximal Eccentric Cycling in People With COPD Acute Whole-Body Cardiopulmonary and Muscle Metabolic Responses
Chest. 2021 Feb;159(2):564-574. Epub 2020 Sep 1. PMID: 32888931
Are the “critical” inspiratory constraints actually decisive to limit exercise tolerance in COPD?
ERJ Open Res. 2020 Aug 17;6(3):00178-2020. PMID: 32832523

Checklist and questions for presenters to integrate into their presentation and to use for moderating the discussion:

What is the stated rationale/motivation for this study?Is this an important clinical/scientific problem?
What is the stated hypothesis (or objective)?Does the hypothesis (or objective) address the stated rationale)?
What are the stated methods used to test the hypothesis (achieve the objective)?Will the methods test the stated hypothesis?
What are the results?Are the results presented appropriately?
What is the authors’ interpretation of the results?Do you agree with their interpretation?
Are they making inferences that go beyond what the data show?
(If a clinical study) Do the findings apply to our patient population?
(If an interventional clinical study) Is the effect size clinically meaningful?
What are the stated limitations of the study?Do you agree with the stated limitations?
Are there other limitations?
Does this study provide the definitive answer the original problem?
Are other studies needed?

RECRU Seminars

RECRU seminars: Fridays at 1pm

October 2, 2020Sushmita Pamidi
October 23, 2020Benjamin Smith
November 6, 2020Deborah Assayag
December 18, 2020Tania Janaudis-Ferreira
January 29, 2021Grant Presentations
February 19, 2021Anne Gonzalez
March 26, 2021John Kimoff
April 30, 2021Marta Kaminska
May 28, 2021Faiz Ahmad Khan
June 18, 2021Kevin Schwartzman