Respiratory Research at the Meakins

Research Themes, Programs and Initiatives

Publications

Our History: Featured Articles and Journal Covers

T Cells and Airway Smooth Muscle Interactions in Asthma

T Cells and Airway Smooth Muscle Interactions in Asthma

July 14, 2014. Perspectives Editorial in the J of Physiology. In the field, it was still unknown whether airway smooth muscle activation by activated T cell binding could also affect airway smooth muscle contractility. Work by the Lauzon group provides evidence for this targeted T cell–airway smooth muscle cell interaction resulting in increased airway smooth muscle shortening velocity. The work shows that inflammatory cells promote airway smooth muscle hypercontractility in airway hyper-responsiveness and asthma. Original publication PMID: 24687581.

Starved Bacteria Can Better Adapt and Survive

Starved Bacteria Can Better Adapt and Survive

Nov 18, 2011. Science Perspectives Feature: Antioxidant strategies to tolerate antibiotics. Publication by Dao Nguyen identified that when bacteria are starved, it allows them to better adapt and survive. Original Nguyen Publication PMID: 22096200.

Pseudomonas aeruginosa and Biofilms: New Insights on Antibiotic Tolerance

Pseudomonas aeruginosa and Biofilms: New Insights on Antibiotic Tolerance

Nov 18, 2011. This Week in Science Feature: Arrest and Tolerate. Publication by Dao Nguyen on Pseudomonas aeruginosa and biofilms: new insights on antibiotic tolerance. Publication shows that antibiotic tolerance occurs, not because the targets of antibiotics have become inactive during growth arrest, but because starvation-sensing mechanisms generate protective responses. Original Publication PMID: 22096200.

Meakins-Christie Laboratories Founded

Meakins-Christie Laboratories Founded

August 1972. The Meakins-Christie Laboratories for Respiratory Research was officially opened in August 1972. From the beginning, the laboratories were designed to be interdisciplinary, and physiologists, physicians, epidemiologists, pathologists, radiologists, and biomedical engineers were invited to participate.