Analytical strategies for identifying genetic contributions to complex disease in diverse populations, molecular evolution, statistical genetics, applied population genetics.
We study genomics and metabolomics to increase our understanding of complex disease and response to interventions in diverse human populations. We develop bioinformatic and computational approaches for the analysis of multi-omics data in genetically structured and vulnerable populations for addressing clinically relevant hypotheses. We are highly collaborative and work in close partnership with physician scientists on clinical studies of human disease.
GENETIC STUDIES OF HUMAN DISEASE
Genetic association studies have identified novel genes and pathways involved in disease and furthered our understanding of differential response to therapies. My group develops computational strategies to accelerate discovery in genomic studies of human disease, with an emphasis on structured and diverse populations. Our current research in this area includes studies of asthma and bronchopulmonary dysplasia in preterm infants (BPD).
INTEGRATIVE METABOLOMICS AND PRECISION MEDICINE
A multi-disciplinary effort is required to advance precision medicine. We develop computational strategies for the analysis and integration of multi-omics data to accelerate biological discovery in clinical studies of complex disease in diverse populations. Our current research in this area includes the coupling of genomics and untargeted metabolomics to identify metabolite quantitative trait loci (mQTLs) that are relevant to postnatal lung development, drug response, and bronchopulmonary dysplasia in extremely preterm infants.
McGill University Genome Quebec Innovation Centre
740 Dr Penfield Ave
Montreal, QC H3A 0G1
Education & Training
PhD, McMaster University, 2004
MSc, University of Guelph, 2000
BSc, University of Guelph, 1996